Synthesis and Characterization of a Hydroxyapatite-Sodium Alginate-Chitosan Scaffold for Bone Regeneration

Bone scaffolds play an important role in promoting the healing of large bone defects. However, type scaffold material, drug loaded into scaffold, and method preparation have a significant impact on scaffold's properties. In this study, we developed composite comprising sodium alginate (SA), chitosan (CS), hydroxyapatite (HA). The stent carries vascular endothelial growth factor (VEGF), wrapped internal microspheres, vancomycin (VAN). microspheres are outer matrix formed by SA, CS, HA, whereas VAN. Using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, scanning electron microscopy analyses, studied contraction rate, swelling, porosity, mechanical properties, degradation, release ability all scaffolds. best as demonstrated results these studies, was HA 6 (SA/CS) 4 @VAN/VEGF scaffold. antibacterial determined using Staphylococcus aureus ( S. ). Cytotoxicity, cell adhesion, osteogenic properties were marrow mesenchymal stem cells. indicate that exhibits good physical, chemical, antibacterial, is, thus, new material with potential.